increased il-17a but decreased il-27 serum levels in patients with multiple sclerosis
نویسندگان
چکیده
background: effector cd4+ t cell subsets play an important role in multiple sclerosis (ms). interleukin-27 (il-27) suppresses th (th1, th2 and th17) cells and dampens autoimmunity and tissue inflammation by promoting the generation of type 1 regulatory t cells (tr1). objective: to identify the relative levels of il-27 and il-17a in ms disease. method: in a case-control study, venous blood was collected from forty ms patients and forty-three healthy subjects as control group. serum levels of il-27 and il-17a were measured by elisa method. results: a significant difference between serum il-17a concentration in patients (120.68 ± 209.85 pg/ml) and control group (67.26 ± 117.76 pg/ml, p=0.016) was found. serum il-27 levels of the ms patients (159.7 ± 581.4 pg/ml) were significantly lower than control subjects (180.35 ± 507.84 pg/ml, p=0.001). conclusion: our findings show decreased levels of il-27 against increasing il-17a levels in patients group which may suggest the suppressive role of il-27 on inflammatory process of ms.
منابع مشابه
Increased IL-17A but Decreased IL-27 Serum Levels in Patients with Multiple Sclerosis
Background: Effector CD4+ T cell subsets play an important role in Multiple Sclerosis (MS). Interleukin-27 (IL-27) suppresses Th (Th1, Th2 and Th17) cells and dampens autoimmunity and tissue inflammation by promoting the generation of Type 1 regulatory T cells (Tr1). Objective: To identify the relative levels of IL-27 and IL-17A in MS disease. Method: In a case-control study, venous blood was c...
متن کاملDecreased serum IL-7 levels in patients with systemic sclerosis.
Sirs, Interleukin-7 (IL-7) was originally defined as a pre-B lymphocyte growth factor and was subsequently found to augment the growth of T lymphocytes. A recent study showed that IL-7 is an anti-fibrogenic factor in pulmonary fibrosis in vitro. In this study, we determined the serum levels of IL-7 in patients with SSc. Forty-three patients with SSc and 28 healthy controls were included in the ...
متن کاملIncreased Serum Levels of IL-17A and IL-23 Are Associated with Decreased Vitamin D3 and Increased Pain in Osteoarthritis
INTRODUCTION Osteoarthritis (OA) is the most common type of arthritis and proinflammatory cytokines have been considered as the main etiologic factor in the pathogenesis of the disease. Serum levels of cytokines, that are associated with innate immunity and TH1 cells, have been analyzed in OA patients, however, there is limited research that profiles cytokines associated with Th17 cells and the...
متن کاملSerum levels of IL-17A increase in Asthma but not in accordance with Serum level of IgE and Asthma Severity
Background and Aims: Recent evidence suggests that T helper (Th) 17 cells are involved in the emergence of asthma. Th17 cells have a key role in inducing inflammation in asthmatic airways thus Interleukin (IL)-17A, the main cytokine of Th17, contributes to airways inflammation. Materials and Methods: We evaluated the level of IL-17A and total immunoglobulin E (IgE) in sera of 100 asthmatic p...
متن کاملThe association of IL-17A polymorphisms with IL-17A serum levels and risk of ischemic stroke
The aim of our study was to investigate the association of interleukin-17A (IL-17A) polymorphisms with IL-17A serum levels and risk of ischemic stroke (IS) in a Chinese population. 392 IS patients and 443 controls were included in this study. The polymorphisms of IL-17A gene were determined by Snapshot SNP genotyping assay and DNA sequencing. Serum IL-17A levels were measured by enzyme-linked i...
متن کاملP37: Decreased Serum Levels of Interleukin-35 Among Patients with Relapsing Remitting Multiple Sclerosis
The regulatory role of interleukin-35 (IL-35) in the immunopathogenesis of multiple sclerosis (MS) is suggested in very few studies. We aimed to measure serum levels of IL-35 among clinically isolated syndrome (CIS) and relapsing-remitting MS (RRMS) patients and evaluate the associations between this cytokine and the disease clinical course. This cross-sectional study was conducted during 2017 ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of immunologyجلد ۱۰، شماره ۱، صفحات ۴۷-۵۴
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023